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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/Congo Red *UltraPure grade* *CAS 573-58-0*/23056/100 mg
产品编号:23056
市  场 价:¥21760.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1088.00
品      牌: AAT Bioquest
公      司:AAT Bioquest
公司分类:
AAT Bioquest/Congo Red *UltraPure grade* *CAS 573-58-0*/23056/100 mg
商品介绍
Overview
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Ex/Em(nm)497/None
MW696.66
CAS#573-58-0
SolventWater
StorageF/D/L
CategoryNeuroBIOLOGy
Beta-AmyloidAnalysis
RelatedNeurologicalStains
BiochemicalAssays
Congored(CR)isthesodiumsaltofbenzidinediazo-bis-1-naphtylamine-4-sulfonicacid.CRiswatersoluble,yieldingaredcolloidalsolution.Itisusedtostaincytoplasmanderythrocytestaininhistology.Apple-greenbirefringenceofCRstainedpreparatesunderpolarizedlightisindicativeforthepresenceofamyloidfibrils.EarlydiagnosisandclassificationofamyloiddepositionanddifferentiationfromotherfibrillardepositsrelyonroutineCR-basedhistochemistry.Thishistologyassayiswidelyusedforthecharacterizationofinvitroamyloidfibrils.Inaddition,CRisalsousedforfluorimetricexaminationofamyloidfibrils.ComparedtoCRinbrightlightCRfluorescenceissimpletoperformandmorepronounced.Althoughnotwidelyused,theCRfluorimetricmethodfordetectingamyloidissimpletousewithahighspecificityandsensitivity,andmaybeappliedsuccessfullytofrozensections.
SpectrumAdvancedSpectrumViewer


References&Citations
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1.   McLaughlinRW,DeStigterJK,SikkinkLA,BadenEM,Ramirez-AlvaradoM.(2006)Theeffectsofsodiumsulfate,glycosaminoglycans,andCongoredonthestructure,stABIlity,andamyloidformationofanimmunoglobulinlight-chainprotein.ProteinSci,15,1710.

2.   InestrosaNC,AlvarezA,DinamarcaMC,Perez-AcleT,ColombresM.(2005)Acetylcholinesterase-amyloid-beta-peptideinteraction:effectofCongoRedandtheroleoftheWntpathway.CurrAlzheimerRes,2,301.

3.   InouyeH,KirschnerDA.(2005)Alzheimer"sbeta-amyloid:insightsintofibrilformationandstructurefromCongoredbinding.SubcellBiochem,38,203.

4.   GiorgadzeTA,ShiinaN,BalochZW,TomaszewskiJE,GuptaPK.(2004)Improveddetectionofamyloidinfatpadaspiration:anevaluationofCongoredstainbyfluorescentmicroscopy.DiagnCytopathol,31,300.

5.   SabateR,EstelrichJ.(2003)Pinacyanolaseffectiveprobeoffibrillarbeta-amyloidpeptide:comparativestudywithCongoRed.Biopolymers,72,455.

6.   KimYS,RandolphTW,ManningMC,StevensFJ,CarpenterJF.(2003)Congoredpopulatespartiallyunfoldedstatesofanamyloidogenicproteintoenhanceaggregationandamyloidfibrilformation.JBiolChem,278,10842.

7.   RybarskaJ,PiekarskaB,StopaB,ZemanekG,KoniecznyL,NowakM,KrolM,RotermanI,Szymczakiewicz-MultanowskaA.(2001)EvidencethatsupramolecularCongoredisthesoleligationformofthisdyeforLchainlamBDaderivedamyloidproteins.FoliaHistochemCytobiol,39,307.

8.   RotermanI,KrUlM,NowakM,KoniecznyL,RybarskaJ,StopaB,PiekarskaB,ZemanekG.(2001)WhyCongoredbindingisspecificforamyloidproteins-modelstudiesandacomputeranalysisapproach.MedSciMonit,7,771.

9.   KhuranaR,UverskyVN,NielsenL,FinkAL.(2001)IsCongoredanamyloid-specificdye?JBiolChem,276,22715.

10.   MichaelH,BrandtLJ,TanakaKE,BerkowitzD,CardilloM,WeidenheimK.(2001)Congo-rednegativecolonicamyloidwithscallopingofthevalvulaeconniventes.GastrointestEndosc,53,653.


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