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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/1,2-Diaminoanthraquinone *CAS 1758-68-5*/15220/25 mg
产品编号:15220
市  场 价:¥27560.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1378.00
品      牌: AAT Bioquest
公      司:AAT Bioquest
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AAT Bioquest/1,2-Diaminoanthraquinone *CAS 1758-68-5*/15220/25 mg
商品介绍
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Ex/Em(nm)352/580
MW238.24
CAS#1758-68-5
SolventDMSO
StorageF/D/L
CategoryEnzymeDetection
RedoxEnzymes
RelatedCellSignalingMolecules
ReactiveOxygenSpecies
BiochemicalAssays
Theroleofnitricoxide(NO)asaputativemediatorofneuronaldeathcanbeunderstoodbestifNOisdetecteddirectly.1,2-Diaminoanthraquinone(DAQ)isaredfluorescentprobethatisusedtodetectnitricoxide(NO)productionsinlivecellandanimals.DAQhasminimalneurotoxiceffectsanditneitherinfluencesnormalevokedfieldpotentialamplitudesnordoesitaffectinductionoflong-termpotentiation(LTP)incomparisontocontrols.DAQisusedtodirectlycapturereleasedNOduringneurodegenerationinvivoandatthecellularsiteofitsgeneration.Thenon-fluorescent1,2-diaminoanthraquinone(DAQ)isinjectedintotheeyesofratswhoseopticnerveisinjuredtoinduceretrogradedegenerationoftheganglioncells.ThereactionproductofDAQwithNOisatriazolewithredfluorescence.TheDAQ-basedmethodologyofNOassessmentisconvenientandapplicabletonumerouslivingsystemsbothinvivoandinvitro.
References&Citations
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1.   GalindoF,KABIrN,GavrilovicJ,RussellDA.(2008)Spectroscopicstudiesof1,2-diaminoanthraquinone(DAQ)asafluorescentprobefortheimagingofnitricoxideinlivingcells.PhotochemPhotobiolSci,7,126.

2.   SeligmanK,SavianiEE,OliveiraHC,Pinto-MaglioCA,SalgadoI.(2008)FloraltransitionandnitricoxideemissionduringflowerdevelopmentinArabidopsisthalianaisaffectedinnitratereductase-deficientplants.PlantCellPhysiol,49,1112.

3.   ZhanJ,GunatilakaAA.(2006)Microbialtransformationofamino-andhydroxyanthraquinonesbyBeauveriabassianaATCC7159.JNatProd,69,1525.

4.   PuttmannB,GerlachEM,KrugerM,BlottnerD.(2005)Neuromuscularcontactsinducenitricoxidesignalsinskeletalmyotubesinvitro.Neurosignals,14,85.

5.   SchuchmannS,AlbrechtD,HeinemannU,vonBohlenundHalbachO.(2002)Nitricoxidemodulateslow-Mg2+-inducedepileptiformactivityinrathippocampal-entorhinalcortexslices.NeurobiolDis,11,96.

6.   vonBohlenundHalbachO,AlbrechtD,HeinemannU,SchuchmannS.(2002)Spatialnitricoxideimagingusing1,2-diaminoanthraquinonetoinvestigatetheinvolvementofnitricoxideinlong-termpotentiationinratbrainslices.Neuroimage,15,633.


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