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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/cAMP AM/20300/1 mg
产品编号:20300
市  场 价:¥3900.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$195.00
品      牌: AAT Bioquest
公      司:AAT Bioquest
公司分类:
AAT Bioquest/cAMP AM/20300/1 mg
商品介绍
Overview
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Ex/Em(nm)None/None
MW401.27
CAS#N/A
SolventDMSO
StorageF/D/L
CategoryGPCR
cAMPGPCRAssays
RelatedDiagnosticMolecules
CellSignaling
BiochemicalAssays
cAMP-AMisthecell-permeantcAMP.AfterpermeationandmetabolicactivationbyesterasesthepolarcAMPisreleasedwhichistrappedinsidethecellandsubsequentlymetabolizedquickly,resultinginapulse-typesignal.cAMPisasecondmessenger,usedforintracellularsignaltransduction,suchastransferringintocellstheeffectsofhormoneslikeglucagonandadrenaline,whichcannotpassthroughtheplasmamembrane.Itisinvolvedintheactivationofproteinkinasesandregulatestheeffectsofadrenalineandglucagon.cAMPalsobindstoandregulatesthefunctionofionchannelssuchastheHCNchannelsandafewothercyclicnucleotide-bindingproteinssuchasEpac1andRAPGEF2.
References&Citations
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1.NicholsJM,MaiellaroI,ABI-JaoudeJ,CurciS,HoferAM.(2015)"Store-operated"cAMPsignalingcontributestoCa2+-activatedCl-secretioninT84coloniccells.AmJPhysiolGastrointestLiverPhysiol,309,G670.

2.ShangJ,LiJ,KellerMP,HohmeierHE,WangY,FengY,ZhouHH,ShenX,RabagliaM,SoniM,AttieAD,NewgardCB,ThornberryNA,HowardAD,ZhouYP.(2015)InductionofmiR-132andmiR-212ExpressionbyGlucagon-LikePeptide1(GLP-1)inRodentandHumanPancreaticbeta-Cells.MolEndocrinol,29,1243.

3.GerasimovaE,LebedevaJ,YakovlevA,ZefirovA,GiniatullinR,SitdikovaG.(2015)Mechanismsofhydrogensulfide(H2S)actiononsynaptictransmissionatthemouseneuromuscularjunction.Neuroscience,303,577.

4.GioinoP,MurrayBG,IanowskiJP.(2014)SEROtonintriggerscAMPandPKA-mediatedintracellularcalciumwavesinMalpighiantubulesofRhodniusprolixus.AmJPhysiolRegulIntegrCompPhysiol,307,R828.

5.BenesicA,SchwerdtG,HennemeierI,SauvantC,MildenbergerS,GekleM.(2014)ThenephrotoxicIfosfamide-metabolitechloroacetaldehydeinterfereswithrenalextracellularmatrixhomeostasis.CellPhysiolBiochem,33,1106.

6.AflakiM,QiXY,XiaoL,OrdogB,TadevosyanA,LuoX,MaguyA,ShiY,TardifJC,NattelS.(2014)ExchangeproteindirectlyactivatedbycAMPmediatesslowdelayed-rectifiercurrentremodelingbysustainedbeta-adrenergicactivationinguineapighearts.CircRes,114,993.

7.RajagopalM,ThomasSV,KathpaliaPP,ChenY,PaoAC.(2014)ProstaglandinE2induceschloridesecretionthroughcrosstalkbetweencAMPandcalciumsignalinginmouseinnermedullarycollectingductcells.AmJPhysiolCellPhysiol,306,C263.

8.IwaseK,IshiharaA,YoshimuraS,AndohY,KatoM,SekiN,MatsumotoE,HiwasaT,MullerD,FukunagaK,TakiguchiM.(2014)ThesecretograninIIgeneisasignalintegratorofglutamateanddopamineinputs.JNeuRochem,128,233.

9.RobertsOL,KamishimaT,Barrett-JolleyR,QuayleJM,DartC.(2013)ExchangeproteinactivatedbycAMP(Epac)inducesvascularrelaxationbyactivatingCa2+-sensitiveK+channelsinratmesentericartery.JPhysiol,591,5107.

10.MeijerLA,ZhouH,ChanOY,AltelaarAF,HennrichML,MohammedS,BosJL,HeckAJ.(2013)QuantitativeglobalphosphoproteomicsofhumanumbilicalveinendothelialcellsafteractivationoftheRapsignalingpathway.MolBiosyst,9,732.


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AAT Bioquest常用产品报价单

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