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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/iFluor 750™ RGD Conjugate/36800/1 mg
产品编号:36800
市  场 价:¥85560.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$4278.00
品      牌: AAT Bioquest
公      司:AAT Bioquest
公司分类:
AAT Bioquest/iFluor 750™ RGD Conjugate/36800/1 mg
商品介绍
Overview
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Ex/Em(nm)750/780
MW~1600
CAS#N/A
SolventDMSO
StorageF/D/L
CategoryGPCR
ReceptorBindingAssays
RelatedCellFunctionalAnalysis
BiochemicalAssays
Near-infraredfluorescenceopticalimaging(alsocalledinvivoImaging)isemergingasapowerfultechnologyforstudyingdiseasesatmolecularlevelinsmallanimalmodels.WaterandBIOLOGicaltissueshaveminimalabsorbanceandautofluorescenceintheNIRwindow(650-900nm),thusallowingefficientphotonpenetrationinto,andoutoftissuewithlowintra-tissuescattering.AcrossthisNIRwindow,lightabsorptionbyphysiologicallyabundantmoleculessuchashemoglobin,oxyhemoglobinanddeoxyhemoglobinisalsoreducedtoaminimum.InvivoimagingsystemswithbiocompatIBLefluorescenceagentsarebeingdevelopedandoptimizedforuseinthenearinfraredspectralregion-ensuringmaximumlightpenetrationandhighestsensitivity.Thecelladhesionmoleculeintegrinisinvolvedinangiogenesisandmetastasisinmanytumortypes.Integrinissignificantlyup-regulatedinactivatedendothelialcellsandfast-growingsolidtumorcells,comparedtoitsminimumexpressioninquiescentbloodvesselsandmostnormaltissues.iFluor™750-labeledmonomericarginine-glycine-asparticacid(RGD)peptidec(RGDyK)specificallytargetsintegrinbothincellcultureandinlivingsubjects.TheinvivoefficacyofiFluor™750-c(RGDyK)dependsonmanyfactors,includingthereceptoraffinity,specificity,molecularsize,overallmolecularcharge,hydrophilicityandmetabolicstABIlity.
SpectrumAdvancedSpectrumViewer

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References&Citations
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1.HuangY,LiuW,GaoF,FangX,ChenY.(2016)c(RGDyK)-decoratedPluronicmicellesforenhanceddoxorubicinandpaclitaxeldeliverytobrainglioma.IntJNanomedicine,11,1629.

2.PandyaDN,HantganR,BudzevichMM,KockND,MorseDL,BatistaI,MintzA,LiKC,WadasTJ.(2016)PreliminaryTherapyEvaluationof(225)Ac-DOTA-c(RGDyK)DemonstratesthatCerenkovRADIationDerivedfrom(225)AcDaughterDecayCanBeDetectedbyOpticalImagingforInVivoTumorVisualization.Theranostics,6,698.

3.JiT,GaoS,LiuZ,XingH,ZhaoG,MaQ.(2016)99mTc-Glu-c(RGDyK)-BombesinSPECTCanReduceUnnecessaryBiopsyofMassesThatAreBI-RADSCategory4onUltrasonography.JNuclMed,57,1196.

4.ChenY,ZhangW,HuangY,GaoF,FangX.(2016)InVivoBiodistributionandAnti-TumorEfficacyEvaluationofDoxorubicinandPaclitaxel-LoadedPluronicMicellesDecoratedwithc(RGDyK)Peptide.PLoSOne,11,e0149952.

5.ChenY,ZhangW,HuangY,GaoF,FangX.(2015)Dual-functionalc(RGDyK)-decoratedPluronicmicellesdesignedforantiangiogenesisandthetreatmentofdrug-resistanttumor.IntJNanomedicine,10,4863.

6.GaoY,ZhouY,ZhaoL,ZhangC,LiY,LiJ,LiX,LiuY.(2015)EnhancedantitumorefficacybycyclicRGDyK-conjugatedandpaclitaxel-loadedpH-responsivepolymericmicelles.ActaBiomater,23,127.

7.GuoL,DingW,ZhengLM.(2014)TheC(RgdyK)-conjugatedFe3O4nanoparticleswithhighdrugloadfordual-targetingintegrinalpha(v)beta3-expressingcancercells.JNanosciNanotechnol,14,4858.

8.OxboelJ,Brandt-LarsenM,Schjoeth-EskesenC,MyschetzkyR,El-AliHH,MadsenJ,KjaerA.(2014)ComparisonoftwonewangiogenesisPETtracers68Ga-NODAGA-E[c(RGDyK)]2and(64)Cu-NODAGA-E[c(RGDyK)]2;invivoimagingstudiesinhumanxenografttumors.NuclMedBiol,41,259.

9.KimJH,KimYH,KimYJ,YangBY,JeongJM,YounH,LeeDS,LeeJS.(2013)Quantitativepositronemissiontomographyimagingofangiogenesisinratswithforelimbischemiausing(68)Ga-NOTA-c(RGDyK).Angiogenesis,16,837.

10.Ocampo-GarciaBE,Santos-CuevasCL,DeLeon-RodriguezLM,Garcia-BecerraR,Ordaz-RosadoD,Luna-GuitierrezMA,Jimenez-MancillaNP,Romero-PinaME,Ferro-FloresG.(2013)Designandbiologicalevaluationof(9)(9)mTc-N(2)S(2)-Tat(49-57)-c(RGDyK):ahybrid


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