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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/Thioflavin T *CAS 2390-54-7*/23060/1 g
产品编号:23060
市  场 价:¥21760.00
场      地:美国(厂家直采)
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美  元  价:$1088.00
品      牌: AAT Bioquest
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AAT Bioquest/Thioflavin T *CAS 2390-54-7*/23060/1 g
商品介绍
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Ex/Em(nm)412/482
MW318.87
CAS#2390-54-7
SolventDMSO
StorageF/D/L
CategoryNeuroBIOLOGy
Beta-AmyloidAnalysis
RelatedNeurologicalStains
BiochemicalAssays
ThioflavinT(ThT),alsocalledBasicYellow1orCI49005,isabenzothiazolesalt.Thedyeisusedtovisualizeplaquescomposedofbeta-amyloidfoundinthebrainsofAlzheimer"sdiseasepatients.Whenitbindstobetasheets,suchasthoseinamyloidoligomers,thedyeundergoesacharacteristic120nmredshiftofitsexcitationspectrumthatmaybeselectivelyexcitedat450nm,resultinginafluorescencesignalat482nm.ThTbindsrapidlyandspecificallytotheanti-parallelbeta-sheetfibrilsformedfromsyntheticbeta-amyloid(1-40),butdoesnotbindtomonomeroroligomericintermediates.ThebindingofThTdoesnotinterferewiththeaggregationofbeta-amyloidpeptideintoamyloidfibrils.
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References&Citations
CitationExplorer

FluorescentdyesinthecontextofDNA-binding:ThecaseofThioflavinT
Authors:AlessandroBiancardi,TaritaBiver,BenedettaMennucci
Journal:InternationalJournalofQuantumChemistry(2017)

FluorescentdyesinthecontextofDNA-binding:ThecaseofThioflavinT
Authors:AlessandroBiancardi,TaritaBiver,BenedettaMennucci
Journal:InternationalJournalofQuantumChemistry(2017)

HumanTelomericHybrid-2-over-Hybrid-1G-quadruplexTargetingandaSelectiveHypersaline-TolerantSensorUsingAbasicSite-EngineeredMonomorphism
Authors:TaoWu,MeiyunYe,TianyiMao,FanLin,YuehuaHu,NingGan,YongShao
Journal:AnalyticaChimicaActa(2017)

DeterminantsofamyloidfibrildegradationbythePDZproteaseHTRA1
Authors:SimonPoepsel,AndreasSprengel,BarbaraSacca,FarnuschKaschani,MarkusKaiser,ChristosGatsogiannis,StefanRaunser,TimClausen,MichaelEhrmann
Journal:Naturechemicalbiology(2015):862--869

ThioflavinTasafluorescenceprobeformonitoringRNAmetabolismatmolecularandcellularlevels
Authors:ShinyaSugimoto,Ken-ichiArita-Morioka,YoshimitsuMizunoe,KunitoshiYamanaka,TeruOgura
Journal:Nucleicacidsresearch(2015):gkv338

Agnanoclustersasprobesforturn-onfluorescencerecognitionofTpGdinucleotidewithahighselectivity
Authors:JianPeng,YongShao,LinglingLiu,LihuaZhang,HuaLiu,YingWang
Journal:Analyticachimicaacta(2014):78--84

MechaNISTicaspectsofthioflavin-Tself-aggregationandDNAbinding:evidencefordimerattackonDNAgrooves
Authors:ABiancardi,TBiver,ABurgalassi,MMattonai,FSecco,MVenturini
Journal:PhysicalChemistryChemicalPhysics(2014):20061--20072

Molecularrotor-basedfluorescentprobeforselectiverecognitionofhybridG-quadruplexandasaK+sensor
Authors:LinglingLiu,YongShao,JianPeng,ChaobiaoHuang,HuaLiu,LihuaZhang
Journal:Analyticalchemistry(2014):1622--1631

Selectiverecognitionofds-DNAcavitiesbyamolecularrotor:switchedfluorescenceofthioflavinT
Authors:LinglingLiu,YongShao,JianPeng,HuaLiu,LihuaZhang
Journal:MolecularBioSystems(2013):2512--2519


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