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主营:研究并生产荧光和发光探针,信号转导研究的试剂
℡ 4000-520-616
℡ 4000-520-616
AAT Bioquest/BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6*/5101/10 g
产品编号:5101
市  场 价:¥49900.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$2495.00
品      牌: AAT Bioquest
公      司:AAT Bioquest
公司分类:
AAT Bioquest/BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6*/5101/10 g
商品介绍
Overview
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Ex/Em(nm)None/None
MW275.34
CAS#58521-49-6
SolventDMF
StorageF
CategoryPeptidesSynthesis
BocAminoAcids
RelatedUnusualAminoAcids
BiochemicalAssays
(3S,4S)-Statineisanovelaminoacidofpepstatin,alowmolecularweightinhibitorofacidproteases.ThisBOC-Statinebuildinglockisaveryusefulprecursorforpreparingprotease-resistantpeptideforpharmaceticalapplicationusingthestandardBOCchemistry.
References&Citations
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1.   CADIcamoCD,AsanteV,AbuAmmarM,BorelliC,KortingHC,KokschB.(2009)InvestigationofthesyntheticroutetopepstatinanaloguesbySPPSusingO-protectedandO-unprotectedstatineasbuildingblocks.JPeptSci,15,272.

2.   LazebnikLB,ZvenigorodskaiaLA,KhomerikiSG,EfremovLI,CherkashovaEA.(2009)[Drug(statine)-inducedhepatitis].EkspKlinGastroenterol,110.

3.   BackM,NyhlenJ,KvarnstromI,AppelgrenS,BorkakotiN,JanssonK,LindbergJ,NystromS,HallbergA,RosenquistS,SamuelssonB.(2008)Design,synthesisandSARofpotentstatine-basedBACE-1inhibitors:explorationofP1phenoxyandbenzyloxyresidues.BioorgMedChem,16,9471.

4.   PreciadoA,WilliamsPG.(2008)Asimplemicroscalemethodfordeterminingtherelativestereochemistryofstatineunits.JOrgChem,73,9228.

5.   RomeoS,ParapiniS,Dell"AgliM,VaianaN,MagroneP,GalliG,SparatoreA,TaramelliD,BosisioE.(2008)Atovaquone-statine"double-drugs"withhighantiplasmodialactivity.ChemMedChem,3,418.

6.   BarazzaA,GotzM,CadamuroSA,GoettigP,WillemM,SteuberH,KohlerT,JestelA,ReinemerP,RennerC,BodeW,MoroderL.(2007)Macrocyclicstatine-basedinhibitorsofBACE-1.Chembiochem,8,2078.

7.   FarranD,ToupetL,MartinezJ,DewynterG.(2007)Stereocontrolledsynthesisof2,4-diamino-3-hydroxyacidsstartingfromdiketopiperazines:anewrouteforthepreparationofstatineanalogues.OrgLett,9,4833.

8.   BridgesKG,ChopraR,LinL,SvensonK,TamA,JinG,CowlingR,LoveringF,AkopianTN,DIBLasio-SmithE,Annis-FreemanB,MarvellTH,LaVallieER,ZollnerRS,BardJ,SomersWS,StahlML,KrizRW.(2006)Anovelapproachtoidentifyingbeta-secretaseinhibitors:bis-statinepeptidemimeticsdiscoveredusingstructureandspotsynthesis.Peptides,27,1877.

9.   ZuoZ,LuoX,ZhuW,ShenJ,ShenX,JiangH,ChenK.(2005)Moleculardockingand3D-QSARstudiesonthebindingmechanismofstatine-basedpeptidomimeticswithbeta-secretase.BioorgMedChem,13,2121.

10.   HuB,FanKY,BridgesK,ChopraR,LoveringF,ColeD,ZhouP,EllingboeJ,JinG,CowlingR,BardJ.(2004)SynthesisandSARofbis-statinebasedpeptidesasBACE1inhibitors.BioorgMedChemLett,14,3457.


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